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CA-Ac exhibits a slower labeling rate and lower affinity for the HaloTag protein
Journal of Medicinal Chemistry 2022
Product Name Azide-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4)-MMAE Synonyms CAS Number Related CAS Molecular Formula C81H135N13O22 Molecular Weight 1643
Product Name Thalidomide-O-C6-amine HCl Synonyms Thalidomide-4'-O-C6-amine HCl CAS Number 2245697-88-3 Related CAS 1957235-98-1 (free base) Molecular Formula C19H24ClN3O5 Molecular Weight 409
DBCO-Lys(m-PEG4)-Val-Ala-PAB dbco-dap-m-PEG4 CA-Ac exhibits a slower labelingSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG,
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