Azide-Propionyl-Val-Ala-PAB(m-PEG8)-Exatecan piperidine HB007 is a small ubiquitin-related

HB007 is a small ubiquitin-related modifier 1 (SUMO1) degrader

89 SMILES ClCCOCCOCCOCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

458 SMILES [N-]=[N+]=NCCOCCOCCOCCOC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

421 Purity (HPLC) >= 95% Solubility DMSO

Azide-Propionyl-Val-Ala-PAB(m-PEG8)-Exatecan piperidine HB007 is a small ubiquitin-relatedSOLU KNEX cleavable linker features a Val Ala dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC