Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan m-peg8-pab 301 SMILES OCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

301 SMILES OCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name HB007 Synonyms CAS Number 2387821-46-5 Related CAS Molecular Formula C15H9ClN4S2 Molecular Weight 344

334 SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC(OCCOCC#C)=CC=C12 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Phthalimidinoglutarimide-5'-propargyl-OH Synonyms CAS Number 2229725-43-1 Related CAS Molecular Formula C16H14N2O4 Molecular Weight 298

Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan m-peg8-pab 301 SMILES OCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by