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CC-3060 is a Cereblon modulator and promotes ZBTB16 degradation by primarily engaging distinct structural degrons on CRBN-ZnF1 zinc finger domains
Product Name CA-PhN3 Synonyms Azidobenzoyl-Halo
Product Name DOTA-tris(t-Bu)ester-C5-azide Synonyms CAS Number n/a Related CAS Molecular Formula C33H62N8O7 Molecular Weight 682
S)-AHPC hydrochloride Synonyms VH 032 CAS Number 1448189-80-7 Related CAS 1448297-52-6 (free base) Molecular Formula C22H32Cl2N4O3S Molecular Weight 503
Azide-Hexanoyl-Val-Ala-PAB(m-PEG8)-MMAE Size:5mg CC-3060 is a Cereblon modulatorSOLU KNEX cleavable linker features a Val Ala dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing
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