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The taselisib-induced degradation of mutant p110a protein is ubiquitin-mediated and proteasome-dependent
467 Purity (HPLC) >= 95% Solubility DMSO
1038/s41589-020-0594-x
Product Name tert-butyl 2-[4-(piperidin-4-yl)piperazin-1-yl]acetate Synonyms CAS Number 688020-38-4 Related CAS Molecular Formula C15H29N3O2 Molecular Weight 283
Propargyl-Gly(m-PEG4)-Val-Cit-PAB-PNP fmoc The taselisib-induced degradation of mutantSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or
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