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Mal-Propionyl-PEG4-Gly-Gly-Phe-Gly-PAB(m-PEG4)-MMAE Size:10mg making the linkers highly adaptable

Description

making the linkers highly adaptable for diverse ADC and related applications

Nature 2016

Product Name DOTA-C5-alcohol Synonyms CAS Number n/a Related CAS Molecular Formula C21H39N5O8 Molecular Weight 489

346 Purity (HPLC) >= 95% Solubility DMSO

Mal-Propionyl-PEG4-Gly-Gly-Phe-Gly-PAB(m-PEG4)-MMAE Size:10mg making the linkers highly adaptableSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a

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