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The taselisib-induced degradation of mutant p110a protein is ubiquitin-mediated and proteasome-dependent
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
Product Name DOTA-tris(t-Bu)ester-NHS Synonyms CAS Number 819869-77-7 Related CAS Molecular Formula C32H55N5O10 Molecular Weight 669
Product Name Thalidomide-5'-O-PEG2-propargyl Synonyms CAS Number n/a Related CAS Molecular Formula C20H20N2O7 Molecular Weight 400
Phthalimidinoglutarimide-5'-propargyl-O-PEG1-C2-amine HCl deuterium-labeled-heterocycle The taselisib-induced degradation of mutantDegrader building block for targeted protein degradation. Contains an E3 ligase ligand with a linker and a function group, which can be conjugated to target protein ligands through straightforward chemical reactions. Product Name Phthalimidinoglutarimide 5' propargyl O PEG1 C2 amine HCl Synonyms CAS Number n a Related CAS Molecular Formula C20H24ClN3O5 Molecular Weight 421. 88 SMILES Cl. NCCOCCOCC#CC1=CC=C2C(CN(C3CCC(=O)NC3=O)C2=O)=C1 Purity (HPLC) >=
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