Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg 193 Purity (HPLC) >= 95%

193 Purity (HPLC) >= 95% Solubility DMSO

559 Purity (HPLC) >= 95% Solubility DMSO

Cy3 CAS Number: N/A Molecular Formula: C32H40N2O5S Molecular Weight: 564

558 SMILES NCCOCCNC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg 193 Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I