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The methylcyclopropene moiety can act as a dienophile in inverse electron-demand Diels-Alder (iEDDA) reactions
Product Name DOTA-tris(t-Bu)ester-PEG5-C2-azide Synonyms CAS Number n/a Related CAS Molecular Formula C40H76N8O12 Molecular Weight 861
SiR-NHS is the NHS ester of SiR-6-COOH (652Ex/674Em) and can be conjugated to amine-containing molecules easily
Product Name Fmoc-Gly-Gly-Phe-Gly-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C55H72N6O16 Molecular Weight 1073
Mal-Propionyl-PEG2-Val-Ala-PAB(m-PEG8)-MMAE sir The methylcyclopropene moiety can actSOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly
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