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Product Name NDB-TM Synonyms CAS Number 871510-38-2 Related CAS Molecular Formula C10H10N4O3S Molecular Weight 266
emission maximum = 660 nm
Product Name Mal-Propionyl-PEG4-Val-Ala-PAB(m-PEG4) Synonyms CAS Number Related CAS Molecular Formula C43H68N6O16 Molecular Weight 925
Product Name tert-butyl 2-[4-(piperidin-4-yl)piperazin-1-yl]acetate Synonyms CAS Number 688020-38-4 Related CAS Molecular Formula C15H29N3O2 Molecular Weight 283
Mal-Propionyl-PEG6-Val-Ala-PAB(m-PEG4)-Exatecan tmr Product Name NDB-TM Synonyms CASSOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I
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