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Ca 2+ signalling is comprised of: i) a stimulus induced transient or sustained increase in the free Ca 2+ concentration [Ca 2+ ], ii) the detection of changes in [Ca 2+ ] by Ca 2+ sensor proteins, iii) a down-stream response triggered by the action of the Ca 2+ sensor proteins and iv) the removal of excess free Ca 2+ (Pirayesh et al., 2021)
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