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The best travel backpacks simply have to be comfortable, and we can tell you from years of experience that the Osprey Farpoint 40 performs excellently when it comes to comfort
This is a 45L backpack, which means it fits a LOT and while it is internally approved for carry-ons which is why many think its the best carry-on backpack for international travel since it is designed to fit most airlines
Maybe some one-off regional models?
To assess the comfort of each model in our review, we took each bag out for various trips, focusing on all manner of activities
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